Scale-up and optimization in preperative chromatography : principles and biopharmaceutical applications / edited by Anurag S. Rathore, Ajoy Velayudhan.
Contributor(s): Rathore, Anurag S. (Anurag Singh) | Velayudhan, Ajoy.
Material type: BookSeries: Chromatographic science: Volume 88.Publisher: New York : Marcel Dekker, 2003Description: 1 online resource (xiii, 342 pages).ISBN: 9780203909287; 9781135564155; 9781135564100; 9781135564148.Subject(s): Biotechnology | Chromatographic analysis | Pharmaceutical technologyAdditional physical formats: Print version: : No titleDDC classification: 615.19 Online resources: Click here to view.chapter 1 An Overview of Scale-Up in Preparative Chromatography / Anurag S. Rathore -- chapter 2 Interaction of Mass Transfer and Fluid Mechanics / Edwin N. Lightfoot -- chapter 3 Optimization of Preparative Separations / Attila Felinger -- chapter 4 Engineering Aspects of Ion-Exchange Chromatography / Peter Watler -- chapter 5 A Simple Approach to Design and Control of Simulated Moving Bed Chromatographs -- chapter 6 Large-Scale Ion-Exchange Chromatography: A Comparison of Different Column Formats -- chapter 7 Development and Operation of a Cation-Exchange Chromatography Process for Large-Scale Purification of a Recombinant Antibody Fragment -- chapter 8 Case Study: Capacity Challenges in Chromatography-Based Purification of Plasmid DNA -- chapter 9 Case Study: Purification of an IgG1 Monoclonal Antibody / Paul K. Ng -- chapter 10 Case Study: Normal Phase Purification of Kilogram Quantities of a Synthetic Pharmaceutical Intermediate -- chapter 11 Case Study: Development of Chromatographic Separation to Remove Hydrophobic Impurities in Alatrofloxacin -- chapter 12 Case Study: Process Development of Chromatography Steps for Purification of a Recombinant E. coli Expressed Protein.
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