<P>1. Regulation of Cytokine Signaling by the JAK-STAT Pathway<BR><I>Nicolette Nadene Houreld</P><P></P></I><P>2. The Structure-Function Bonhomie of JAK-STAT Molecules<BR><I>Ritobrata Goswami</P><P></P></I><P>3. MicroRNA-Mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases<BR><I>Chandra S. Boosani, Wanlin Jiang, Taylor Burke and Devendra K. Agrawal</P><P></P></I><P>4. JAK-STAT Signaling in Asthma and Allergic Airway Inflammation<BR><I>Amina Abdul Qayum, Tristan Hayes and Mark H. Kaplan</P><P></P></I><P>5. Role of JAK-STAT Signaling in Atopic Dermatitis<BR><I>Radomir M. Slominski and Matthew J. Turner</P><P></P></I><P>6. JAK/STAT Signaling Pathway and Gliosis in Neuroinflammatory Diseases<BR><I>Han-Chung Lee, Kai-Leng Tan, Pike-See Cheah and King-Hwa Ling</P><P></P></I><P>7. JAK-STAT Signaling in Cardiovascular Disease<BR><I>George W. Booz, Raffaele Altara and Sean P. Didion</P><P></P></I><P>8. Diabetes and Obesity: Abnormal JAK-STAT Signaling<BR><I>Marcia J. Abbott</P><P></P></I><P>9. JAK-STAT Signaling in Liver Fibrosis<BR><I>Marwa K. Ibrahim and Noha G. Bader El Din</P><P></P></I><P>10. Renal Disorders: Involvement of JAK-STAT Pathway<BR><I>Yuji Nozaki</P><P></P></I><P>11. JAK-STAT Signaling in Hematologic Malignancies<BR><I>Thomas Pincez and Thai Hoa Tran</P><SUP><P></P></I></SUP><P>12. Aberrant JAK-STAT Signaling in Hematopoietic Malignancies<BR><I>Parvis Sadjadian</P><P></P></I><P>13. Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling<BR><I>Daniel Silberger and Duy Pham </P><P></P></I><P>14. Targeting JAK-STAT Pathway for Various Inflammatory Diseases and Viral Infections<BR><I>Christina Gavegnano and Raymond F. Schinazi</P></I>

JAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.

OCLC-licensed vendor bibliographic record.