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Collagen Biografts for Tunable Drug Delivery [electronic resource] / by Rucha Joshi.

By: Joshi, Rucha [author.].
Contributor(s): SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: SpringerBriefs in Applied Sciences and Technology: Publisher: Cham : Springer International Publishing : Imprint: Springer, 2021Edition: 1st ed. 2021.Description: XII, 107 p. 41 illus., 30 illus. in color. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783030638177.Subject(s): Biomedical engineering | Regenerative medicine | Materials | Biotechnology | Biomedical Engineering and Bioengineering | Regenerative Medicine and Tissue Engineering | Materials Engineering | BiotechnologyAdditional physical formats: Printed edition:: No title; Printed edition:: No titleDDC classification: 610.28 Online resources: Click here to access online
Contents:
Introduction -- Creating Tunable Collagen Matrices - An Approach Inspired by In-Vivo Collagen Synthesis and Self-Assembly -- Application of Collagen Fibril Biografts for Enhancing Local Vascularization in an In-Vivo Chick Chorioallantoic Membrane (CAM) Model -- Appendix A: Type I Collagen Based Drug Delivery Formats -- Appendix B: State-of-the-Art Methods of Tuning Collagen Based Molecular Release.
In: Springer Nature eBookSummary: This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen ; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.
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Introduction -- Creating Tunable Collagen Matrices - An Approach Inspired by In-Vivo Collagen Synthesis and Self-Assembly -- Application of Collagen Fibril Biografts for Enhancing Local Vascularization in an In-Vivo Chick Chorioallantoic Membrane (CAM) Model -- Appendix A: Type I Collagen Based Drug Delivery Formats -- Appendix B: State-of-the-Art Methods of Tuning Collagen Based Molecular Release.

This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen ; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.

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