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Computational Genomic Signatures [electronic resource] / by Ozkan Ufuk Nalbantoglu, Khalid Sayood.

By: Nalbantoglu, Ozkan Ufuk [author.].
Contributor(s): Sayood, Khalid [author.] | SpringerLink (Online service).
Material type: materialTypeLabelBookSeries: Synthesis Lectures on Biomedical Engineering: Publisher: Cham : Springer International Publishing : Imprint: Springer, 2011Edition: 1st ed. 2011.Description: XVI, 113 p. online resource.Content type: text Media type: computer Carrier type: online resourceISBN: 9783031016509.Subject(s): Engineering | Biophysics | Biomedical engineering | Technology and Engineering | Biophysics | Biomedical Engineering and BioengineeringAdditional physical formats: Printed edition:: No title; Printed edition:: No titleDDC classification: 620 Online resources: Click here to access online
Contents:
Genome Signatures, Definition and Background -- Other Computational Characterizations as Genome Signatures -- Measuring Distance of Biological Sequences Using Genome Signatures -- Applications: Phylogeny Construction -- Applications: Metagenomics -- Applications: Horizontal DNA Transfer Detection.
In: Springer Nature eBookSummary: Recent advances in development of sequencing technology has resulted in a deluge of genomic data. In order to make sense of this data, there is an urgent need for algorithms for data processing and quantitative reasoning. An emerging in silico approach, called computational genomic signatures, addresses this need by representing global species-specific features of genomes using simple mathematical models. This text introduces the general concept of computational genomic signatures, and it reviews some of the DNA sequence models which can be used as computational genomic signatures. The text takes the position that a practical computational genomic signature consists of both a model and a measure for computing the distance or similarity between models. Therefore, a discussion of sequence similarity/distance measurement in the context of computational genomic signatures is presented. The remainder of the text covers various applications of computational genomic signatures in the areas ofmetagenomics, phylogenetics and the detection of horizontal gene transfer. Table of Contents: Genome Signatures, Definition and Background / Other Computational Characterizations as Genome Signatures / Measuring Distance of Biological Sequences Using Genome Signatures / Applications: Phylogeny Construction / Applications: Metagenomics / Applications: Horizontal DNA Transfer Detection.
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Genome Signatures, Definition and Background -- Other Computational Characterizations as Genome Signatures -- Measuring Distance of Biological Sequences Using Genome Signatures -- Applications: Phylogeny Construction -- Applications: Metagenomics -- Applications: Horizontal DNA Transfer Detection.

Recent advances in development of sequencing technology has resulted in a deluge of genomic data. In order to make sense of this data, there is an urgent need for algorithms for data processing and quantitative reasoning. An emerging in silico approach, called computational genomic signatures, addresses this need by representing global species-specific features of genomes using simple mathematical models. This text introduces the general concept of computational genomic signatures, and it reviews some of the DNA sequence models which can be used as computational genomic signatures. The text takes the position that a practical computational genomic signature consists of both a model and a measure for computing the distance or similarity between models. Therefore, a discussion of sequence similarity/distance measurement in the context of computational genomic signatures is presented. The remainder of the text covers various applications of computational genomic signatures in the areas ofmetagenomics, phylogenetics and the detection of horizontal gene transfer. Table of Contents: Genome Signatures, Definition and Background / Other Computational Characterizations as Genome Signatures / Measuring Distance of Biological Sequences Using Genome Signatures / Applications: Phylogeny Construction / Applications: Metagenomics / Applications: Horizontal DNA Transfer Detection.

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