ch. 1. Introduction to dermatokinetics / Ya-Ting Wu, Yuri G. Anissimov, and Michael S. Roberts -- ch. 2. Theoretical models for dermatokinetics of therapeutic agents / Rong Shi and Hartmut Derendorf -- ch. 3. Formulation approaches to modulate the dermatokinetics of drugs / Srinivasa Murthy Sammeta, Michael A. Repka, and S. Narasimha Murthy -- ch. 4. Conventional methods of cutaneous drug sampling / Jose Juan Escobar-Chavez, Miriam Lopez-Cervantes, and Adriana Ganem Rondero -- ch. 5. Cutaneous microdialysis / Grazia Stagni --ch. 6. Sampling substrates by skin permeabilization / M. Begona Delgado-Charro -- ch. 7. Spectroscopic techniques in dermatokinetic studies / Georgios N. Stamatas -- ch. 8. Regulatory perspective of dermatokinetic studies / April C. Braddy and Dale P. Conner.

Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, is imperfect, and may allow certain topically applied substances or toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of nature of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover the introductory aspects significance, methods, and models used in dermatokinetic studies of therapeutic agents.Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents; Drug Delivery Approaches to Modulate Dermatokinetics of Drugs; Conventional Methods of Cutaneous Drug Sampling; Cutaneous Microdialysis; Sampling Substrates by Skin Permeabilization; Spectroscopic Techniques in Dermatokinetics Studies; Regulatory Perspective of Dermatokinetic Studies--Provided by publisher.