"Version: 202303"--Title page verso.

Includes bibliographical references.

1. Introduction / Les Satin. part I. Molecules mediating calcium influx. 2. Calcium channel selectivity and permeation : function meets 3D structure / Richard W. Tsien -- 3. Structure and function of TRP channels / Gilbert Q. Martinez and Eric N. Senning -- 4. Glutamate-gated calcium currents in the central nervous system : structural determinants, regulatory mechanisms, and biological functions / Gary J. Iacobucci and Gabriela K. Popescu

part II. Calcium signaling on channels and other effectors. 5. Monitoring the dynamics of calcium signaling effectors using genetically encoded fluorescent biosensors / Yanghao Zhong, Sohum Mehta and Jin Zhang -- 6. Calcium-activated potassium channels / Alberto J. Gonzalez-Hernandez, Aravind Kshatri and Teresa Giraldez -- 7. Calcium-activated chloride channels / Alec Kittredge, Aaron P. Owji, Sara Ragi, Stephen H. Tsang, Yu Zhang and Tingting Yang

part III. Physiological roles of calcium. 8. Excitation-contraction coupling in skeletal muscle : fast Ca2+ signaling for muscle activation / Martin F. Schneider and Erick O. Hern�andez-Ochoa -- 9. Voltage-gated Ca2+ channels and excitation-secretion coupling at the synapse / Brittany Williams, Jessica R. Thomas and Amy Lee -- 10. Calcium signaling in context : case studies in endocrine cells / Patrick A. Fletcher and Arthur S. Sherman

part IV. Calcium channels in organelles. 11. Characterization of endo-lysosomal cation channels using calcium imaging / Christian Wahl-Schott, Marc Freichel, Volodymyr Tsvilovsky and Hristo Varbanov -- 12. The structural era of the mitochondrial calcium uniporter / Enrique Balderas, Salah Sommakia, David Eberhardt, Sandra Lee and Dipayan Chaudhuri

part V. Calcium channels and disease. 13. Voltage-gated calcium channelopathies / John W. Hussey, Kevin G. Herold and Ivy E. Dick -- 14. Role of dysregulated calcium in neuropsychiatric diseases / Herie Sun and Anjali M. Rajadhyaksha.

Written by expert contributors, this much-needed book emphasizes a quantitative and comprehensive perspective to explore the many dimensions of cellular Ca2+ signalling. Leading researchers in the field of calcium signaling present key aspects of this process in cells, starting with Ca2+ entry into the cell, its uptake from the cytosol by organelles, such as the endoplasmic reticulum and mitochondria, and the actions of Ca2+ in turn on a variety of important cellular regulatory processes. This research and reference text should prove useful to a wide readership, from students to researchers at many different levels, particularly in physiology, pharmacology, or biomedical engineering. Part of Biophysical Society-IOP series.

Graduate students and researchers in physiology, pharmacology, or biomedical engineering.

Also available in print.

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

Dr. Leslie S. Satin is the Joanne I. Moore Endowed Research Professor of Pharmacology of the University of Michigan Medical School. He obtained his PhD from UCLA in the laboratory of D. Junge and conducted postdoctoral work at Stony Brook University with P.R. Adams and at the University of Washington, Seattle, with D. Cook. His research has focused on calcium signaling, ion channels, oscillations, and stimulus-secretion coupling in pancreatic beta cells. Manu Ben-Johny is an Assistant Professor in the Department of Physiology and Cellular Biophysics at Columbia University. He received a BS in Biomedical Engineering and Mathematics from Saint Louis University, and subsequently completed his PhD in Biomedical Engineering at Johns Hopkins University under the tutelage of David Yue. His lab focuses on the biophysics and physiology of voltage-gated sodium and calcium ion channels that shape cardiac and neuronal action potentials and in developing nature-inspired approaches to manipulate ion channel function. Ivy E. Dick is an assistant professor in the Physiology Department at the University of Maryland, School of Medicine. She began her career under the direction of Drs Charles Cohen and Owen McManus at Merck Research Labs and subsequently earned her doctoral degree under the direction of Dr. David Yue in the Biomedical Engineering department at Johns Hopkins University, where she studied the mechanisms underlying calmodulin regulation of voltage-gated calcium channels. Dr. Dick's current research focuses on understanding the mechanisms of voltage-gated calcium channel regulation, and how genetic mutations disrupt channel function.

Title from PDF title page (viewed on March 31, 2023).