000 04329nam a22005415i 4500
001 978-1-4471-5298-9
003 DE-He213
005 20200421111841.0
007 cr nn 008mamaa
008 130917s2013 xxk| s |||| 0|eng d
020 _a9781447152989
_9978-1-4471-5298-9
024 7 _a10.1007/978-1-4471-5298-9
_2doi
050 4 _aQH324.2-324.25
072 7 _aPSA
_2bicssc
072 7 _aUB
_2bicssc
072 7 _aCOM014000
_2bisacsh
082 0 4 _a570.285
_223
245 1 0 _aModels and Algorithms for Genome Evolution
_h[electronic resource] /
_cedited by Cedric Chauve, Nadia El-Mabrouk, Eric Tannier.
264 1 _aLondon :
_bSpringer London :
_bImprint: Springer,
_c2013.
300 _aXII, 328 p. 86 illus., 45 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aComputational Biology,
_x1568-2684 ;
_v19
505 0 _aPart I: Emergence of Standard Algorithms -- What's Behind Blast -- Forty Years of Model-Based Phylogeography -- How to Infer Ancestral Genome Features by Parsimony -- Duplication, Rearrangement and Reconciliation -- The Genesis of the DCJ Formula -- Part II: New Lights on Current Paradigms -- Large-Scale Multiple Sequence Alignment and Phylogeny Estimation -- Rearrangements in Phylogenetic Inference -- Status of Research on Insertion and Deletion Variations in the Human Population -- A Retrospective on Genomic Preprocessing for Comparative Genomics -- A Comparison of DCJ and Algebraic Distances -- Part III: Promising Directions -- Fractionation, Rearrangement, Consolidation, Reconstruction -- Error Detection and Correction of Gene Trees -- The Potential of Family-Free Genome Comparison -- Genetic History of Populations.
520 _aThis authoritative text/reference presents a review of the history, current status, and potential future directions of computational biology in molecular evolution. Gathering together the unique insights of an international selection of prestigious researchers, this must-read volume examines the latest developments in the field, the challenges that remain, and the new avenues emerging from the growing influx of sequence data. These viewpoints build upon the pioneering work of David Sankoff, one of the founding fathers of computational biology, and mark the 50th anniversary of his first scientific article. Topics and features: Discusses the development of the BLAST algorithm, model-based phylogeography techniques, and the double cut and join (DCJ) distance formula Reviews the reconstruction of evolutionary features of ancestral genomes in a known phylogeny, and presents integrative models of evolution Introduces algorithms to estimate alignment and phylogeny on ultra-large datasets, and an approach for using likelihood methods with rearrangement models Examines the impact of insertion and deletion variants in human biology, evolution and health Surveys novel and recent research on genomic distance and family-free genome comparison Describes consolidation methods for reconstruction of ancestral gene orders, and error detection in gene tree construction Investigates  the genetic events recoverable from simulations of human population histories The broad spectrum of rich contributions in this essential collection will appeal to all computer scientists, mathematicians and biologists involved in comparative genomics, phylogenetics and related areas.
650 0 _aComputer science.
650 0 _aComputer science
_xMathematics.
650 0 _aBioinformatics.
650 0 _aBiomathematics.
650 1 4 _aComputer Science.
650 2 4 _aComputational Biology/Bioinformatics.
650 2 4 _aMathematical and Computational Biology.
650 2 4 _aBioinformatics.
650 2 4 _aMathematics of Computing.
700 1 _aChauve, Cedric.
_eeditor.
700 1 _aEl-Mabrouk, Nadia.
_eeditor.
700 1 _aTannier, Eric.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781447152972
830 0 _aComputational Biology,
_x1568-2684 ;
_v19
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4471-5298-9
912 _aZDB-2-SCS
942 _cEBK
999 _c55566
_d55566