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001 9781351042468
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006 m d
007 cr |||||||||||
008 191217s2020 flua o 000 0 eng d
040 _aOCoLC-P
_beng
_erda
_epn
_cOCoLC-P
020 _a9781351042444
_q(ePub ebook) :
020 _a1351042440
020 _a9781351042451
_q(PDF ebook) :
020 _a1351042459
020 _a9781351042437
_q(Mobipocket ebook) :
020 _a1351042432
020 _a9781351042468
_q(ebook) :
020 _a1351042467
020 _z9781138487628 (hbk.)
024 7 _a10.1201/9781351042468
_2doi
035 _a(OCoLC)1144781695
035 _a(OCoLC-P)1144781695
050 4 _aRB113
072 7 _aMED
_x044000
_2bisacsh
072 7 _aSCI
_x017000
_2bisacsh
072 7 _aSCI
_x049000
_2bisacsh
072 7 _aPSB
_2bicssc
082 0 4 _a616.07
_223
245 0 0 _aJak-STAT signaling in diseases /
_cedited by Ritobrata Goswami.
250 _a1st.
264 1 _aBoca Raton :
_bCRC Press,
_c2020.
300 _a1 online resource :
_billustrations (black and white, and colour)
336 _atext
_2rdacontent
336 _astill image
_2rdacontent
337 _acomputer
_2rdamedia
338 _aonline resource
_2rdacarrier
500 _a<P>1. Regulation of Cytokine Signaling by the JAK-STAT Pathway<BR><I>Nicolette Nadene Houreld</P><P></P></I><P>2. The Structure-Function Bonhomie of JAK-STAT Molecules<BR><I>Ritobrata Goswami</P><P></P></I><P>3. MicroRNA-Mediated Regulation of JAK-STAT Signaling in Non-Cancerous Human Diseases<BR><I>Chandra S. Boosani, Wanlin Jiang, Taylor Burke and Devendra K. Agrawal</P><P></P></I><P>4. JAK-STAT Signaling in Asthma and Allergic Airway Inflammation<BR><I>Amina Abdul Qayum, Tristan Hayes and Mark H. Kaplan</P><P></P></I><P>5. Role of JAK-STAT Signaling in Atopic Dermatitis<BR><I>Radomir M. Slominski and Matthew J. Turner</P><P></P></I><P>6. JAK/STAT Signaling Pathway and Gliosis in Neuroinflammatory Diseases<BR><I>Han-Chung Lee, Kai-Leng Tan, Pike-See Cheah and King-Hwa Ling</P><P></P></I><P>7. JAK-STAT Signaling in Cardiovascular Disease<BR><I>George W. Booz, Raffaele Altara and Sean P. Didion</P><P></P></I><P>8. Diabetes and Obesity: Abnormal JAK-STAT Signaling<BR><I>Marcia J. Abbott</P><P></P></I><P>9. JAK-STAT Signaling in Liver Fibrosis<BR><I>Marwa K. Ibrahim and Noha G. Bader El Din</P><P></P></I><P>10. Renal Disorders: Involvement of JAK-STAT Pathway<BR><I>Yuji Nozaki</P><P></P></I><P>11. JAK-STAT Signaling in Hematologic Malignancies<BR><I>Thomas Pincez and Thai Hoa Tran</P><SUP><P></P></I></SUP><P>12. Aberrant JAK-STAT Signaling in Hematopoietic Malignancies<BR><I>Parvis Sadjadian</P><P></P></I><P>13. Immunodeficiency: Consequences of Mutations in JAK-STAT Signaling<BR><I>Daniel Silberger and Duy Pham </P><P></P></I><P>14. Targeting JAK-STAT Pathway for Various Inflammatory Diseases and Viral Infections<BR><I>Christina Gavegnano and Raymond F. Schinazi</P></I>
520 _aJAK-STAT pathway is one of the few signal transduction pathways that transduce signals involved in multiple homeostatic biological processes including cell differentiation and proliferation, cell death, hematopoiesis and immune responses. JAK-STAT is an elegant pathway that is relatively simple and evolutionary conserved as gene expression is regulated by external parameters. Activated by growth factors or cytokines, this signal transduction cascade regulates the transcription of genes at the nucleus. Mutations and polymorphisms in JAK-STAT pathway are associated with inflammatory diseases and cancers that could impede regular homeostasis. Features: Details activation and microRNA-mediated regulation of JAK-STAT pathway Provides exclusive information about the association of the pathway in various diseases including allergic inflammation, neuro-inflammatory disorder, atopic dermatitis hematopoietic malignancies, cardiovascular disorder, renal disorder, immunodeficiency, liver fibrosis, diabetes and obesity that affect individuals across the globe Clinical relevance of the signaling cascade has been discussed in context of novel class of therapeutics that targets this pathway. An overview of JAK-STAT signaling pathway and the structure-function relationship of different domains of the cascade are discussed. This book provides detailed information on various diseases that are associated with JAK-STAT pathway. It will act as a very good reference book for basic science researchers, academicians, industry professionals involved in translational research leading to product development. This book will excite future professionals towards better understanding of the regulation of this pathway, its association with other signaling cascades to design novel therapeutics.
588 _aOCLC-licensed vendor bibliographic record.
650 0 _aJAK-STAT pathway.
_914539
650 0 _aPathology, Molecular.
_914540
650 7 _aMEDICAL / Immunology
_2bisacsh
_910729
650 7 _aSCIENCE / Life Sciences / Cytology
_2bisacsh
_910908
650 7 _aSCIENCE / Life Sciences / Biology / Molecular Biology
_2bisacsh
_910910
700 1 _aGoswami, Ritobrata,
_eeditor.
_914541
856 4 0 _3Taylor & Francis
_uhttps://www.taylorfrancis.com/books/9781351042468
856 4 2 _3OCLC metadata license agreement
_uhttp://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf
942 _cEBK
999 _c70730
_d70730