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020 _a9783031023880
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024 7 _a10.1007/978-3-031-02388-0
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050 4 _aQC685-689.55
050 4 _aTA1671-1707
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082 0 4 _a621,366
_223
100 1 _aMohammad-Hadi, Layla.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981156
245 1 0 _aApplications of Minimally Invasive Nanomedicine-Based Therapies in 3D in vitro Cancer Platforms
_h[electronic resource] /
_cby Layla Mohammad-Hadi, Marym Mohammad-Hadi.
250 _a1st ed. 2021.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2021.
300 _aXIII, 93 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSynthesis Lectures on Materials and Optics,
_x2691-1949
505 0 _aPreface -- Acknowledgments -- Introduction -- Photodynamic Therapy and Photochemical Internalization -- Photosensitizers and Therapeutic Agents Used in PDT and PCI -- The Use of Nanoparticles in PDT and PCI -- 3D in vitro Cancer Models -- The Applications of PDT and PCI in 3D in vitro Cancer Models -- Authors' Biographies.
520 _aMinimally invasive techniques such as Photodynamic Therapy (PDT) and Photochemical Internalisation (PCI) have for years been under investigation for the treatment of solid cancers. A significant number of the recent research studies have applied PDT and PCI to biological three-dimensional (3D) cancer platforms with many of the studies also involving the use of nanoparticles in order to enhance the efficacy of these light-based therapies. Interest in the employment of 3D cancer platforms has increased considerably due to the ability of the platforms to mimic in vivo models better than the conventional two-dimensional (2D) cultures. Some of the advantages of the 3D cancer systems over their 2D counterparts include improved interaction between cancer cells and the surrounding extracellular matrix (ECM) as well as restricted drug penetration which would allow optimization of treatments prior to undertaking of in vivo studies. The different chapters of this book will discuss photosensitizers and nanoparticles used in PDT and PCI in addition to the applications of these treatments in various 3D cancer models.
650 0 _aLasers.
_97879
650 0 _aMaterials science.
_95803
650 1 4 _aLaser.
_931624
650 2 4 _aMaterials Science.
_95803
700 1 _aMohammad-Hadi, Marym.
_eauthor.
_4aut
_4http://id.loc.gov/vocabulary/relators/aut
_981157
710 2 _aSpringerLink (Online service)
_981158
773 0 _tSpringer Nature eBook
776 0 8 _iPrinted edition:
_z9783031002526
776 0 8 _iPrinted edition:
_z9783031012600
776 0 8 _iPrinted edition:
_z9783031035166
830 0 _aSynthesis Lectures on Materials and Optics,
_x2691-1949
_981159
856 4 0 _uhttps://doi.org/10.1007/978-3-031-02388-0
912 _aZDB-2-SXSC
942 _cEBK
999 _c85117
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